Deciphering the connection between dementia and cardiovascular disease

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Prevent and delay dementia, a growing problem in actual society, is a public health priority.

The project
Who is behind

Dementia is one of the most important problems in today's modern societies with an estimated social and healthcare costs 818 billion dollars, a figure that will double in 2030. Thus, preventing and/or delaying the cognitive decline associated with dementia is currently an important public health priority.

Dementia, at least in its early stages, can be reversible. The changes in the Alzheimer's disease brain can begin 20 years or more before the onset of the symptoms, and thus, it is essential to be able to identify the preclinical stages of this disease and to develop preventive measures to delay cognitive deterioration. Hence, if the progression of this disease to dementia could be slowed down in subjects at risk for just 12 months, by the year 2050 we could have 9.2 million fewer cases of Alzheimer worldwide. Therefore, delaying the onset of dementia may represent an important strategy in the management of this condition, since at present Alzheimer is a deadly disease with no cure or effective treatment.

A clear relationship between cardiovascular health and the development of dementia has been observed. Various cardiovascular risk factors have been associated with the development of cognitive impairment in people without dementia over the years, establishing a clear link between the heart and the brain.

What is our goal?

Despite the increasing awareness of the relationship between CVD and dementia, there are still insufficient studies that have shed light on the mechanisms involved in these events at the genomic or proteomics level. The development of a predictive panel of molecular markers is of vital importance for the entire healthcare system.

We aim to gain a better understanding of the mechanisms underlying the development of dementia at the molecular level in a cohort of individuals with cardiovascular risk factors, as well as to identify potential predictive markers for the development of this disease and therapeutic targets.

Differences in plasma proteins from patients with dementia, with and without cardiovascular affectation may provide the key about the influence of the different cardiovascular risk factors. These studies on a specific cohort of patients are of particular interest as there are currently no automated analytic techniques available that can provide this type of information.

Our project will attempt, for the first time, to decipher molecular and clinical aspects for prevention and treatment of dementia in patients with cardiovascular disease. The project is design to address the need to find mechanisms related to both pathologies, as well as to identify new therapeutic targets and, in this way, help to delay the development of dementia, improving the prognosis and evolution of these patients. 

Who will benefit from our project?

The development of dementia and cardiovascular profiles would allow patients to be more rapidly assessed by healthcare professionals, which would facilitate and improve the management of the former. Furthermore, a reliable diagnosis of patients could reduce the number of subsequent check-up visits required. Coupled with the fact that relatively cheap and rapid detection methods can be used, these procedures would greatly reduce the costs to National Health Services when managing dementia.

Do you want more information?

In our web site you can know a little bit more about the members of the group, learn about our daily life, the different projects and learn about different techniques employed in our research. Moreover, we share our scientific publications, participation in national and international congress, as well as the participation in different events like the International Day of Women and Girls in Science, Brain Awareness Week or Science Week.

Visit us in: https://ecardioresearch.wordpress.com/

Recently, we have publish an informative video for Brain Awareness Week about our project, you can see it in: https://www.youtube.com/watch?v=0YyeDcTt8bQ

Follow us in social networks:

  • Facebook: https://www.facebook.com/e-cardio-research-242915309555292
  • Twitter: @ecardioresearch

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C/Pintor Murillo, 15
28100 Alcobendas (Madrid) - España
T.+(00 34) 91 425 09 09
info@precipita.es
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